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Bìol. Tvarin, 2015, volume 17, issue 2, pp. 50–56
http://doi.org/10.15407/animbiol17.02.050

PHYSIOLOGICAL AND BIOCHEMICAL PROCESSES IN THE ORGANISMS OF RATS THAT WERE FED WITH DIFFERENT AMOUNTS OF GERMANIUM CITRATE

O. P. Dolaychuk, R. S. Fedoruk, I. I. Kovalchuk, S. Y. Kropyvka

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Institute of Animal Biology NAAS,
Laboratory of ecological physiology and quality of productions,
38 Vasyl Stus str., Lviv 79034, Ukraine

Organic germanium compounds are characterized by a wide spectrum of effect on the organisms of people and animals and are used as a food supplement to enhance the immunological organism reactivity. However, using of the toxic inorganic forms as precursors for obtaining organic germanium compounds by chemical synthesis indicates the urgency of searching for the alternative ways to get them. This article presents the results of the study of the influence of different amounts of germanium citrate, which was obtained by electric impulse nanotechnology method, onto the physiological processes in rat organismto determine the optimal dose. The germanium citrate solutions with the concentrations of 10, 200, and 300 µg of Ge/L were used in the study. It was determined that feeding with germanium with the concentration of 10 µg of Ge/L did not show significant changes of the studied parameters. While an elevated concentration of hemoglobin, circulating immune complexes, and average weight molecules were observed in the blood of the rats, which were fed with germanium citrate with the concentrations of 200 and 300 µg of Ge/L. Such changes may indicate the immunomodulatory properties of the germanium citrate. Probable decrease in the concentration of the lipid hydroperoxides and TBA-active products in the blood of the animals, which were fed with the germanium citrate with the concentrations of 200 and 300 µg of Ge/L of water, was also found out. More effective physiological influence of the germanium onto the peroxidation processes was noticed in case of feeding its citrate with the concentrations of 200 and 300 µg of Ge/L. So feeding with the germanium citrate, produced with the help of the nanotechnology method, improves the immunological indicators and reduces the intensity of the lipid peroxidation of the infant rats.

Keywords: GERMANIUM NANOAQUACITRATE; IMMUNOBIOLOGICAL INDICATORS; HAEMATOLOGY; RATS; BLOOD; INTERNAL ORGANS

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