CHOLESTEROL METABOLISM IN RATS UNDER EFFECTS OF CHITOSAN AND DEAE-CELLULOSE
M. Marounek, Z. Volek, E. Skřivanová, O. Savka, L. Kalachnyuk, G. Kalachnyuk
Comparative study on effects of chitosan and DEAE-cellulose on cholesterol metabolism in rats was presented here. Research results shown that chitosan significantly decreases the cholesterol level in the blood serum and in the liver. Here it has been discovered the tendency of decrease of relative expression of LDL-receptor mRNA. DEAE-cellulose had lower effect.
Results of study have shown that neither cholesterol supplementation nor aminated polysaccharides influenced activity of HMG-CoA reductase, which is the rate-limiting enzyme of cholesterol synthesis.
Key words: CHITOSAN, DEAE-CELLULOSE, CHOLESTEROL, LIPIDS, BLOOD SERUM, LIVER, CAECUM, LDL-RECEPTOR mRNA
