INFLUENCE OF HYPOXIA ON OXYGEN HOMEOSTASIS AND ACID-BASE BALANCE IN THE ORGANISM OF THE FETUS AND NEWBORN ANIMALS

Bìol. Tvarin, 2016, volume 18, issue 4, pp. 40–46 http://dx.doi.org/10.15407/animbiol18.04.040

INFLUENCE OF HYPOXIA ON OXYGEN HOMEOSTASIS AND ACID-BASE BALANCE IN THE ORGANISM OF THE FETUS AND NEWBORN ANIMALS

M. D. Kambur,¹ A. A. Zamaziy², E. M. Livoschenko¹, L. V. Plyuta¹, A. V. Pihtyrova¹, S. V. Ostapenko¹, O. N. Natyagluy¹

This email address is being protected from spambots. You need JavaScript enabled to view it.

¹Sumy National Agrarian University,
160 H. Kondrateva str., Sumy 40021, Ukraine

²Poltava State Agricultural Academy,
1/3 Scovorody str., Poltava 30003, Ukraine

Obtaining viable posterity is one of the urgent problems of production. The research results indicate that in the state of hypoxia up to 30–37 % of the calves and 20–25 % of pigs are born and 90 % of them die in the first hours or days after birth. However, of the known literary sources, the influence of hypoxia on oxygen homeostasis and acid-base balance of the fetus and newborn animals are not very clear.

In the article the research results of oxygen homeostasis and acid-base balance indicators of the fetus and newborn animals are presented. It is established that depending on the degree of hypoxia action during the prenatal growth and development calves are born in a state of mild (adequate spontaneous respiratory movements), medium (inadequate spontaneous respiratory movements after birth) and severe hypoxia (animals are born with no signs of respiratory or meconium in the amniotic fluid), and pigs in a state of severe hypoxia. Effect of hypoxia on the fetus causes a decrease of blood pH in newborn animals that is accompanied with 1.66 times increased content of hydrogen ions in the blood. Acidotic shift in organism of animals born in a state of hypoxia is accompanied by hypoxia and hypercapnia, 1.35–1.25 times (P<0.01) decreased partial pressure of oxygen, 1.56–1.37 times (P<0.01) increased partial pressure of carbon dioxide.

On average, the supply of tissues with oxygen in calves of experimental groups were 1.25 times less than in clinically healthy calves (P<0.01). The greatest number of dead piglets and piglets in a state of hypoxia is born in the third part of the generative process. Acidotic shift in the body of the fetus and newborn animals of the experimental group is characterized by increased anaerobic glycolysis, a decrease the content of bases in the blood (P<0.01).

Keywords: HYPOXIA, ACIDOSIS, HOMEOSTASIS, NEWBORN ANIMALS, FETUS, RESPIRATION, GROWTH, DEVELOPMENT

1. Afanasieva L. V., Kalinovsky G. I. Morphology of placenta barrier of blood. Veterinary medicine, 2008, no. 6, 35 p. (in Ukrainian)

2. Anderson D. E., Rings M. D. Current Veterinary Therapy: Food Animal Practice, 5^th Ed. Saunders, St. Louis MO, 2009, pp. 178–179.

3. Chaykina M. Usual unmaturing of pregnancy: factors of development and feature of therapy. Successes of modern biology, 2008, ed. no. 5 (14), pp. 10–12. (in Russian)

4. Gomela T. L., Cannigam M. D. Neonatology. Moscow, Medicine, 1995, 636 p. (in Russian)

5. Grigorieva G. I. Haemoglobin and adaptations to the hypoxia for mammals. Successes of modern biology, 1978, no. 2, pp. 238–253. (in Russian)

6. Groenendaal F., Vries L. S. Selection of babies for intervention after asphyxia. Semin. Neonatal., 2000, vol. 5, no. 7, pp. 17–32. https://doi.org/10.1053/siny.1999.0119

7. Ivashkiv R. M., Kidla I. M., Dybiniak L. V. An estimation of the state of recreation of high-performance cows is on results the obstetric health centre system. Scientific announcer of the Lviv state academy of veterinary medicine named after of S. Z. Gzhytsky. Lviv, 2009, no. 2, pp. 84–90. (in Ukrainian)

8. Pone W. F. Factord affecting the survival of pig of embrions. Theriogenology, 1985, vol. 23, no. 1, pp. 91–105. https://doi.org/10.1016/0093-691X(85)90075-5

9. Smith B. P. Large Animal Internal Medicine. 3^rd Ed. Mosby-Elsevier Publishing, St. Louis, MO, 2009, 493 p.

10. Studenkina M. Y., Kyltsa U. G., Eggersa G. A. Prenatal pathology. Moscow, Medicine, 1984, 268 p. (in Russian)

11. Zamaziy A. A. Influence of hypoxia is on the haematological indexes of calves. Announcer of the Sumy national agrarian university, 2009, no. 3 (24), pp. 25–28. (in Ukrainian)

12. Zayko M. N., Buc G. M. Physiopathology. Kyiv, Medicine. 2008, 704 p. (in Ukrainian)

Download full text in PDF format

The Animal Biology

Search