THE CONDITION OF ANTIOXIDATIVE SYSTEM UNDER RESPIRATORY PATHOLOGY IN CALVES AND APPLICATION OF MEDICINAL PRODUCTS «FLOVET 30%» AND «FLORYCOL»
V.P. Muzyka
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State Scientific Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donets’ka str., 11, Lviv, 79019, Ukraine
Most of diseases of young agricultural animals, in particular respiratory diseases, are developed on the background of intensification of peroxidation processes, antioxidative protection decrease and accumulation in tissues of toxic oxidation products that demonstrate cytotoxic, genotoxic, mutational, oncogenic effects. The aim of work was to study the intensiveness of lipid peroxidation processes and activity of antioxidative protection in calves suffering from respiratory diseases under conditions of application of «Flovet 30%» and «Florycol». The sick calves suffering from respiratory diseases caused by streptococcal, staphylococcal and pneumococcal infections were the material for testing. The sick animals were treated with «Flovet 30%» (control group) and «Florycol» (treated group). The sick animal organism is characterized by increased level of lipid peroxidation processes, accumulation of intermediate and finished oxidation products and decreased activity of enzymatic link of antioxidative protection. The high content of lipid hydroperoxides and TBA-active products were detected in blood plasma of sick animals. The activity of superoxide dismutase, glutathione peroxidase and catalase of erythrocytes is characterized by low indices. In 15 days after application of «Flovet 30%» and «Florycol» we observed the increase of enzyme activity of antioxidative system of calf organism and decreases of lipid peroxidation processes. It is worth noting that on the 7th day of experiment we observed higher activity of glutathione peroxidase and catalase than at application of «Flovet 30%» in blood of sick animals as a result of application of «Florycol». The detected changes caused the decrease of intensiveness of clinic sign manifestation of disease as a result of application of «Florycol» and full disappearance of signs was observed 3 days earlier than as a result of application of «Flovet 30%».
