Bìol. Tvarin, 2019, volume 21, issue 4, pp. 51–57

RESISTANCE OF THE RABBIT ORGANISM UNDER EFFECT OF DIFFERENT AMOUNTS OF NANO ZINC CITRATE AND ITS COMBINATION WITH COBALT AND CHROME CITRATE

YVLesyk, I.V.Luchka, N. O. Bosanevych, H. H. Denys, OSGrabovska

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Institute of Animal Biology NAAS,
38 Vasyl Stus str., Lviv, 79034, Ukraine

The article presents the results of the study of the effect of feeding rabbits from the 62nd to the 86th day of life with different amounts of nano zinc citrate in combination with cobalt and chromium citrates obtained by using nanotechnology on indicators of cellular and humoral immunity in their body. It has been established that the feeding of rabbits after weaning of zinc citrate, depending on the amount used, significantly influenced the formation of cellular and humoral mechanisms of non-specific resistance of their body. The blood tests of rabbits of the second experimental group showed significantly higher between-group differences in the relative content of FA (P<0.05) and LASK (P<0.01) at 24 days of the study, which indicates the stimulating effect of the applied amounts of organic zinc compound on its cellular level specific resistance of their body. A higher (P<0.05–0.001) concentration of protein-bound hexoses, sialic acids, and ceruloplasmin in the blood of rabbits I, II, and III of the study groups was observed during the study, indicating the peculiarities of the action of different amounts of zinc citrate on the processes of formation of immunophysiological reactivity. Because the functional properties of glycoproteins depend on the composition and chemical structure of the hydrocarbon moiety of their molecule, alteration of the structure of the carbohydrate components of glycoproteins can cause impaired intercellular interaction, which determines the adhesive properties and immunogenicity of cells. The use of all amounts of organic zinc citrate supplement in the diet of rabbits in combination with chromium and cobalt citrates had a stimulating effect on the functioning of their body’s immune system, which led to a significant increase (P<0.050.001) in the content of immunoglobulins in blood studies compared with their values in animals of the control group, indicating the activating effect of zinc citrate on the synthesis of individual classes of immunoglobulins in the lymphatic system.

Keywords: RABBITS, IMMUNOPHYSIOLOGICAL REACTIVITY, ZINC NANOACVACITRATE, COBALT CITRATE, CHROMIUM CITRATE, RESISTANCE, IMMUNOGLOBULIN, GLYCOPROTEINS

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