Activity of indicators of the humoral immunity unit of calves for the action of pyridoxine hydrochloride

О. Jaremko, M. Verkholiuk, R. Peleno, V. Semanyuk

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Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv,
50 Pekarska str., Lviv, 79010, Ukraine

The article presents the data of the effect of different doses of pyridoxine hydrochloride on the activity of humoral immunity in the blood serum of calves of the dairy growing period. The lowest activity of the indicators of humoral immunity was found in the serum of calves for the first day of life in all research groups. Exogenous administration of pyridoxine hydrochloride to colostrum and milk led to changes in the studied parameters. It was found that the bactericidal activity of serum increases on the 21^st day of calf life and slightly decreases on the 90^th day. The addition of pyridoxine hydrochloride at different doses to the milk leads to a probable increase in bactericidal activity of the serum only at doses of 4.0 mg/kg body weight at 60 and 90 days (P<0.05) and 5.0 mg/kg body weight from 21 90 days (P<0.05). Serum lysozyme activity increases during ontogeny and under the action of exogenous pyridoxine hydrochloride. A significant difference between the lysozyme activity indices of the control and experimental groups was established in calves of II, III, IV and V groups on the 60^th and 90^th day (P<0.05, P<0.01). Complementary activity of serum increases during ontogenesis, and additional introduction of pyridoxine hydrochloride has led to its decrease. A significant decrease in the complementary activity of serum was detected in calves at doses of 4 mg/kg body weight on the 90^th day (P<0.05) and 5 mg/kg body weight from 21^st to 90^th day (P<0.05, P<0.01).

Key words: calves, bactericidal activity of blood serum, lysozyme activity of blood serum, complementary activity of blood serum, pyridoxine hydrochloride

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