Elemental composition of liver and kidney tissues of rats under the influence of fungicides

S. V. Khyzhnyak, A. O. Velinskaya, E. V. Byschuk, V. M. Voitsitskiy

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National University of Life and Environmental Sciences of Ukraine,
15 Heroyiv Oborony str., Kyiv, 03041, Ukraine

Widespread use of fungicides in various spheres of human life leads to negative consequences for both humans and the environment. The article presents the results of a study of the acute effect of systemic fungicides of the chemical class triazoles on the content of macro- and microelements in kidney and liver rat tissues. The content of chemical elements was determined by inductively coupled plasma atomic emission spectrometry. The established changes in the content of macro- and microelements in the rat liver and kidney indicate tissue specificity of the fungicidal action. Under the influence of fungicide containing tebuconazole in amount of 250 g/dm³ or combined fungicide containing (tebuconazole, 125 g/dm³ + triadimefon, 100 g/dm³) the content of Potassium (K), Calcium (Ca), Chromium (Cr), Iron (Fe), Copper (Cu) and Zinc (Zn) increased sugnificantly (P<0.05) in liver. This can lead to a functional load on the organ. Contrary, in kidney the studied fungicides cause the decrease (P<0.05) in the content of trace elements (Zn, Mn, Cr), Zn:Cu ratio and increase in the Fe content, which may indicate the oxidative metabolic disorders in the organ, but an increase in the Ca content (P<0.05) — characterize the permeability of cell membranes. The detected changes in the content of macro- and microelements in the kidney and liver tissues may be the dysfunction and altering the effectiveness of intracellular control and effector signals.

Key words: fungicides, liver, kidneys, elements, dysfunction

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