ADJUSTMENT OF STATE ANIMAL ORGANISM VACCINATIONS IMMYNOMODULATO THE EXAMPLE OF «AMIKSYN» IN APPLYING THE COMPLEX VACCINES «HIPRABOVIS-4» YOUNG CATTLE
N. Kharchenko
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State Scientific Control Institute of Biotechnology and strains of microorganisms,
Donetska str., 30, Kyiv, 03151, Ukraine
Lately, the vaccination of animals there are many complications, unexpected reactions or drug is ineffective. The immune response to complex vaccine in calves formed slower than the adult population, because the vaccine is multi-component and ensures the production of antibodies against several diseases at the same time, which is a great burden on a young body. Such influence is not included in the standard documentation, that is why in such cases it is necessary to use drugs with immunokorrektiruyuschie action that significantly increase the effectiveness of such combined polaczen. When setting us menosprecio actions vaccine «Hyprabovis-4», we decided to use immunomodulator in the scheme of vaccination. In this paper, the results of biochemical indices of immune protection and prooxidant-antioxidant system in calves during the application of a comprehensive vaccine «Hyprabovis-4» and combined it with the drug immunocorrective action «Amiksin». The results obtained give grounds to assert that this immunomodulator significantly accelerates the formation of circulating immune complexes, increases the antibacterial properties of whey of blood of animals and prevents monostreams action components of the vaccine on the body. Because earlier in the experimental animals was reduced levels of total protein, it globulin fractions, circulating immune complexes (CIC) and increased content seromucoides, after application of the preparation «Amiksin» the content of the CEC and lizotsymus activity significantly increased (p<0.05), and the number seromucoid remained almost constant during the experiment. Significant changes from the side of the antioxidant protection system in control animals and two research groups have found. The JC and MDA remained the same in comparison with the values of the control animals for experimentation, which is a certificate of the balance in the oxidant-anticonvalsion the homeostasis of the investigated animals.
Keywords: TOTAL PROTEIN, CIC, SEROMUCOIDES, LIZOTSIMYS ACTIVITY, IMMYNE REACTIVITY, IMUNOMODULYATORIS, COMPLEX VACCINE, MALONIC DYALDEHID, DIENE CONJUGATES, ANTIOXIDATIVE ACTIVITY OF BLOOD SERUM
