NONSPECIFIC RESISTANCE IN PIGLETS' BLOOD WITH COLIENTEROTOXEMIA AND FOR SPECIFIC
ACTION OF GAMMA GLOBULIN
M. I. Ratskyy, O. I. Vischur, K. B. Smolyaninov, N. A. Broda, N. M. Leshovska, D. I. Mudrak, I. Ye. Solovodzinska
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Institute of Animal Biology NAAS, str. Vasyl Stus, 38, Lviv, 79034, Ukraine
The use specific γ-globulin to increase stress resistance and resistance to colienterotoxemia of piglets at weaning is caused by several factors. According to WHO recommendations, one of the most important areas of application of immunoglobulin preparations is the prevention and treatment of bacterial and viral infections. The main immunological properties of antibodies IgG and IgA isotypes are high affinity for pathogens so that they able to neutralize bacterial toxins, reduce the infectivity of viruses, block the attachment of bacteria to cells.
Two experiments on pigs of large white breed of 28-day old were conducted. The first experiment was carried out on clinically healthy and pigs with colienterotoxemia. The second experiment was conducted on 2 groups of clinically healthy pigs, with 10 heads in every group. Piglets of experimental group 3 days before weaning were injected intramuscularly specific γ-globulin at a dose of 1 ml/kg of body weight, re-administration of the drug was performed on the 12-th day after weaning. Control group of piglets, respectively, in those periods were administered isotonic sodium chloride solution.
The clinical manifestation of colienterotoxemia inhibits phagocytosis, as shown by reduced phagocytic activity of blood neutrophils (p < 0.01). The content of circulating immune complexes in the serum of ill piglets was significantly higher (p < 0.05) than pigs in the control group. The low levels of cellular and humoral (lysozyme activity of blood serum) protective factors, as well as a high content of CIC in piglets from sows after weaning, indicating a negative effect of weaning on immune defenses have been demonstrated . Administration to piglets before weaning specific γ-globulin leads to activation of the immune system in studied animals.
Keywords: PIGLETS, GAMMA-GLOBULIN, BLOOD, KOLIENTEROTOKSEMIYA, THE IMMUNE SYSTEM
