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Kamratska O. Morphological and immunological profile of piggles blood under the influence of feed additive “Globigen Jump Start” and adverse microclimate parameters. Bìol Tvarin. 2025; 27 (4): 53–57. DOI: 10.15407/animbiol27.04.062.
https://doi.org/10.15407/animbiol27.04.062
Received 26.10.2025 ▪ Revision 11.01.2026 ▪ Accepted 15.01.2026 ▪ Published online 16.02.2026

Morphological and immunological profile of piggles blood under the influence of feed additive “Globigen Jump Start” and adverse microclimate parameters

Olesia Kamratska
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Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv, 50 Pekarska str., Lviv, 79010, Ukraine

The article presents the results of a study of the influence of adverse microclimate parameters on the morphological and immunological blood parameters of piglets in the neonatal period of development, and also evaluates the effectiveness of the use of the feed additive “Globigen Jump Start” to correct the identified violations. The study was conducted under production conditions with elevated air temperature and above-normal indoor ammonia concentration. It was established that deviations of microclimate parameters from reference values negatively affect the functional state of the piglets’ organism, which is manifested by changes in hematological and immunological blood parameters. The use of a feed additive containing egg immunoglobulins IgY, β-glucans and mannan-oligosaccharides increased the level of erythrocytes, hemoglobin and hematocrit (P<0.05–0.01), and also contributed to the normalization of the ratio of individual forms of blood leukocytes, in particular, an increase in the proportion of lymphocytes and a decrease in the number of neutrophils. The results obtained indicate a pronounced immunomodulatory and adaptogenic effect of the feed additive “Globigen Jump Start” and the feasibility of its use to increase the adaptive capacity and resistance of the piglet organism in the critical period of early postnatal development under the influence of environmental stress factors.

Key words: piglets, neonatal period, microclimate, heat stress, immunity, hematological indicators, feed additive, IgY

1. Anuta A, Wang X, Kinay P. The impacts of climate change on livestock: An interdisciplinary, scoping review of health, production, and adaptation strategies. Climat Smart Agric. 2025; 2 (4): 100082. DOI: 10.1016/j.csag.2025.100082.
2. Capotă R, Ciaușu-SliwaD, Bostănaru-Iliescu AC, Năstasă V, Mareș M. Latest findings in immunoglobulin Y technologies and applications. Int J Mol Sci. 2025; 26 (13): 6380. DOI: 10.3390/ijms26136380.
3. Choi H, Kim SW. Characterization of β-glucans from cereal and microbial sources and their roles in feeds for intestinal health and growth of nursery pigs. Animals. 2023; 13 (13): 2236. DOI: 10.3390/ani13132236.
4. Chuaychu SB, Sirisereewan C, Techakriengkrai N, Tummaruk P, Thanawongnuwech R, Nedumpun T. Enhancement of systemic virus-specific T lymphocyte responses in pigs supplemented with algae-derived β-glucan. Vet J. 2024; 306: 106182. DOI: 10.1016/j.tvjl.2024.106182.
5. Else KJ, Cruickshank SM. The role of ecoimmunology in tackling the emerging threats of climate change and the exposome. Nat Immunol. 2025; 26: 2113–2115. DOI: 10.1038/s41590-025-02342-0.
6. Heuß EM, Pröll-Cornelissen MJ, Neuhoff C, Tholen E, Große-Brinkhaus C. Invited review: Piglet survival: benefits of the immu Animal. 2019; 13 (10): 2114–2124. DOI: 10.1017/S1751731119000430.
7. Imberti L, Tiecco G, Logiudice J, Castelli F, Quiros-Roldan E. Effects of climate change on the immune system: A narrative review. Health Sci Rep. 2025; 8 (4): e70627. DOI: 10.1002/hsr2.70627.
8. Kozłowska E, Agier J, Różalska S, Jurczak M, Góralczyk-Bińkowska A, Żelechowska P. Fungal β-glucans shape innate immune responses in human peripheral blood mononuclear cells (PBMCs): An in vitro study on PRR regulation, cytokine expression, and oxidative balance. Int J Mol Sci. 2025; 26 (13): 6458. DOI: 10.3390/ijms26136458.
9. Ohorodnyk N, Tkachuk V, Motko N, Boyko A, Pavkovych Correction of cellular and humoral links immunity in piglets under the weaning condition. Sci Horiz. 2025; 28 (1): 9–18. DOI: 10.48077/scihor1.2025.09.
10. Pêgo AC, Lima IS, Martins AC, Sá-Pereira I, Martins G, Gozzelino R. Infection vs. reinfection: The immunomodulation of erythropoiesis. Int J Mol Sci. 2024; 25(11): 6153. DOI: 10.3390/ijms25116153.
11. Pereira KHNP, Fuchs KM, Mendonça JC, Xavier GM, Knupp FC, Lourenço MLG. Topics on maternal, fetal and neonatal immunology of dogs and cats. Vet Immun Immunopathol. 2023; 266: 110678. DOI: 10.1016/j.vetimm.2023.110678.
12. Pornanek P, Phoemchalard C. Dietary supplementation of beta-glucan-rich molasses yeast powder on antibody response to swine fever virus and hematology of starter-grower pigs. Trop Anim Health 2021; 53 (1): 43. DOI: 10.1007/s11250-020-02431-2.
13. Prudyus T, Vishchur O, Mudrak D, Gutsol A, Gutsol N. The state of T- and B-cell links of specific immunity and activity of humoral factors of natural defence of sows and their piglets under the influence of Saccharomyces Cerevisiae yeast complex and enzymes. Sci Horiz. 2025; 28 (2): 9–22. DOI: 10.48077/scihor2.2025.09.
14. Prudyus TY, Vishchur OI, Smolyaninov KB, Mudrak DI, Broda NA, Masyuk MB, Smolyaninova OO. Use of Feed Additive “Globilen Jump Start” in Feeding Piglets. The methodological recommen Ed. by Salyha YT. Lviv, Institute of Animal Biology NAAS, 2025: 24 p. (in Ukrainian)
15. Tester RF, Al-Ghazzewi F. Mannans and health, with a special focus on glucomannans. Food Res Intern. 2013; 50 (1): 384–391. DOI: 10.1016/j.foodres.2012.10.037.
16. Vishchur OI, Guty BV, Gufriy DF, Khariv II, Solovodzinska IE. Immune Status, Assessment Methods and Correction Methods in Young Calves. A monograph. Lviv, Spolom, 2015: 183 p. (in Ukrainian)
17. Vishchur O, Smolyaninov K, Ohorodnyk N. NO-dependent processes in biology, medicine and livestock. In: Topical Issues of the Development of Veterinary Medicine and Breeding Technologies. A scientific monograph. Latvia, Baltija Publishing, 2022: 31–44. DOI: 10.30525/978-9934-26-258-6-2.
18. Vlizlo VV (ed.), Fedoruk RS, Ratych IB. Laboratory Research Methods in Biology, Animal Husbandry and Veterinary Medicine. A Handbook. Lviv, Spolom, 2012: 764 p. (in Ukrainian)
19. Vorobel M, Klym O, Kaplinskyi V, Petryshyn M, Prudyus T, Smolianinova O, Stefanyshyn O, Tsap M, Pylypets A, Luchka I. The effectiveness of the influence on the emission of harmful gases from pig manure during storage in lagoons the addition of mineral fertilizers. Sci Pap Ser D Anim Sci. 2024; 67 (1): 339–345. Available at: https://animalsciencejournal.usamv.ro/index.php/scientific-papers/current?id=1394