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The effect of drugs “Enteronormin” and “Zeleris” on the antioxidant potential of young calves

O. O. Prokopenko, K. B. Smolyaninov, O. I. Vishchur, D. I. Mudrak, N. A. Broda, M. B. Masyuk, O. O. Smolyaninova, A. V. Voltornisty

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Institute of Animal Biology NAAS, 38 V. Stusa St., Lviv, 79034, Ukraine

The article deals with study of the effect of the synbiotic drug “Enteronormin” in a complex with the trace elements iodine and selenium on the indicators of lipid peroxidation and the activity of antioxidant protection system in the body of calves and to the comparison of its action with the antibiotic “Zeleris”. In the last decade, the study of the role of various essential trace elements in various aspects of the regulation of metabolic homeostasis and the state of the immune potential of young cattle remains relevant. In this concern, it is important to emphasize the role of iodine and selenium, as well, as biologically active compounds of new products, among which synbiotic drugs are becoming widespread. In view of this, the development of new effective immunotropic drugs, their comparative study with existing drugs and traditional antimicrobial drugs, such as antibiotics, is actual. Therefore, the purpose of the research, the results of which are presented in this article, was to conduct a comparative study of the effect of the antibiotic “Zeleris” and the complex use of the synbiotic drug “Enteronormin” together with iodine and selenium on the indicators characterizing the activity of lipid peroxidation processes and the level of antioxidant protection system in the body of young calves. As a result of the research, it was found that feeding calves the drug “Enteronormin” in combination with selenium and iodine leads to an increase in the activity of the enzyme glutathione peroxidase and the level of reduced glutathione in the erythrocytes of calves, which is noted at 50- and 60-day age. Such changes, in turn, logically lead to a decrease in the number of lipid peroxidation products in their body. In contrast, we did not detect similar effects from the use of the antibiotic “Zeleris” during the study. Thus, it is concluded that feeding calves with the drug “Enteronormin” together with iodine and selenium leads to an increase in the activity of the key enzyme of the antioxidant defense system — glutathione peroxidase and the level of reduced glutathione in the erythrocytes of the blood of calves. These changes, in turn, lead to a decrease in the number of lopid peroxidation products in their body. However, similar effects from the use of the antibiotic “Zeleris” were not detected. The data obtained may indicate a positive effect of the drug “Enteronormin” in combination with iodine and selenium on the activity of the antioxidant defense system in the body of calves.

Key words: calves, glutathione peroxidase, reduced glutathione, TBA-active products, hydroperoxides, iodine, selenium