THESTATEOFNATURALMECHANISMSOFDEFENCE OF WEANING-PIGLETS FOR ACTIONS OF IMMUNOTROPIC PREPARATION
N. Z. Ohorodnyk1, O. I. Vischur1, V. P. Mizyk2
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1Institute of Animal Biology NAAS; V. Stus Str., 38, Lviv, 79034, Ukraine
2Podolski State Agricultural and Technical University, str. Shevchenko, 13, Kamenetz-Podolsk, 32300,Khmelnitsky region,Ukraine
It is known that the weaning piglets from sows causes stress for them which is accompanied strengthening of processes of lipids peroxidation, inhibits activity of the system of antioxidant defence what results in the decline of nonspecific resistance, development of immunodeficit. It is set that vitamins, minerals and amino acid, reduce the negative influence of stress on the organism of animals. For today wide application of liposomal preparations which along with the usual forms are characterized considerably higher efficiency.
The aim of work was finding out of influence of vitamins (A, D3, E), L-arginine, Zinc, Selenium and Cobalt in form liposomal emulsion on activity of cellular and humoral link of nonspecific resistance of organism of piglets. Researches are conducted on the piglets of large white breed, to which for 2 days before weaning intramuscular introduction the indicated components in form of liposomal preparation in a dose of 0.1 ml/kg of body weight. As a result of the conducted researches set, that weaning piglets from sows draws the inhibits influence on activity of cellular and humoral factors of natural resistance, to what the reliable decline in serum of blood bactericide activity, diminishing in blood the number of monocytes phagocytic, testifies in the reaction of macrophage transformation of mononuclears and decline of phagocytar index. Parenteral introduction the piglets of vitamins (A, D3, E), L-arginine, Zinc, Selenium and Cobalt in the form of liposomal emulsion assisted to the increase of phagocytar index and number and also increase the phagocytar activity of neutrophils of blood in all investigated period the period after weaning. Components of liposomal preparation induced to high levels of piglets index macrophage transformation of mononuclears by increasing the number macrophages nonphagocytic. It is set, increase of bactericide and lisocyme activity and the reduction of levels of circulator immune complexes in the serum blood of piglets of experimental group compared to the control in the period after weaning from sows.
Keywords: PIGLETS, STRESS, WEANING, LIPOSOMAL PREPARATION, NONSPECIFIC RESISTANCE, CELLULAR AND HUMORAL LINK
