Bìol. Tvarin. 2021; 23 (1): 44–46.
Received 10.07.2020 ▪ Accepted 10.03.2021 ▪ Published online 01.04.2021

Research progress on the dairy cow mastitis

Ping Xu

This email address is being protected from spambots. You need JavaScript enabled to view it.

Faculty of Veterinary Medicine, Sumy National Agrarian University,
160 Herasima Kondratieva str., Sumy, 40021, Ukraine

Mastitis is an inflammatory disease of the mammary gland, which has a significant economic impact and is an animal welfare concern. Mammary gland development and regression was directly related with cow lactation. Many different microbial and environmental factors can induce mastitis. Escherichia coli and Staphylococcus aureus were the main cause of mastitis. The treatment of clinical and subclinical mastitis mainly focuses on the use of antibiotics. At present, although some progress has been made in the clinical diagnosis, antibiotic treatment, and pathogenesis control of dairy cow mastitis, the molecular mechanism of the pathogenicity of dairy cow mastitis was still not very clear. So, it is important to understand the mechanisms controlling the immune response at the molecular level. Non-coding RNAs play an important role in various biological processes, including cell proliferation, differentiation and apoptosis. However, their functions and profiles in dairy cows are largely unknown. This study reviewed the research progress of the pathogenesis, prevention measures and immune mechanism of dairy cow mastitis.

Key words: dairy cow, mastitis, etiology, immune mechanism, research status

  1. Bradley A. Bovine mastitis: an evolving disease. J. 2002; 164 (2): 116–128. DOI: 10.1053/tvjl.2002.0724.
  2. Burvenich C, Van Merris V, Mehrzad J, Diez-Fraile A, Duchateau L. Severity of coli mastitis is mainly determined by cow factors. Vet. Res. 2003; 34 (5): 521–564. DOI: 10.1051/vetres:2003023.
  3. Elling R, Chan J, Fitzgerald KA. Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression. J. Immunol. 2016; 46 (3): 504–512. DOI: 10.1002/eji.201444558.
  4. Ganda EK, Gaeta N, Sipka A, Pomeroy B, Oikonomou G, Schukken YH, Bicalho RC. Normal milk microbiome is reestablished following experimental infection with Escherichia coli independent of intramammary antibiotic treatment with a third-generation cephalosporin in bovines. Microbiome. 2017; 5 (1): 74. DOI: 10.1186/s40168-017-0291-5.
  5. He G, Ma M, Yang W, Wang H, Zhang Y, Gao MQ. SDF-1 in mammary fibroblasts of bovine with mastitis induces EMT and inflammatory response of epithelial cells. J. Biol. Sci. 2017; 13 (5): 604–614. DOI: 10.7150/ijbs.19591.
  6. Hogeveen H, Huijps K, Lam TJGM. Economic aspects of mastitis: new developments. New Zeal. Vet. J. 2011; 59 (1): 16–23. DOI: 10.1080/00480169.2011.547165.
  7. Jin W, Ibeagha-Awemu EM, Liang G, Beaudoin F, Zhao X, Guan LL. Transcriptome microRNA profiling of bovine mammary epithelial cells challenged with Escherichia coli or Staphylococcus aureus bacteria reveals pathogen directed microRNA expression profiles. BMC Genom. 2014; 15 (1): 181. DOI: 10.1186/1471-2164-15-181.
  8. Lawless N, Foroushani ABK, McCabe MS, O’Farrelly C, Lynn DJ. Next generation sequencing reveals the expression of a unique miRNA profile in response to a gram-positive bacterial infection. Plos One. 2013; 8 (3): e57543. DOI: 10.1371/journal.pone.0057543.
  9. Seegers H, Fourichon C, Beaudeau F. Production effects related to mastitis and mastitis economics in dairy cattle herds. Res. 2003; 34 (5): 475–491. DOI: 10.1051/vetres:2003027.
  10. Wang H. Identification and functional verification of lncRNA related to mastitis in dairy cows. Northwest Agriculture and Forestry Technology University. 2018. (in Chinese)
  11. Wang X, Xiu L, Hu Q, Cui X, Liu B, Tao L, Wang T, Wu J, Chen Y, Chen Y. Deep sequencing-based transcriptional analysis of bovine mammary epithelial cells gene expression in response to in vitro infection with Staphylococcus aureus Plos One. 2013; 8 (12): e82117. DOI: 10.1371/journal.pone.0082117.
  12. Wei T, Yang M, Tang Q, Zhong R. Research progress of long-chain non-coding RNA in immune inflammatory response. Med. 2015; 30 (10): 1044–1047. DOI: 10.3969/j.issn.1673-8640.2015.10.019. (in Chinese)
  13. Wellnitz O, Bruckmaier RM. The innate immune response of the bovine mammary gland to bacterial infection. J. 2012; 192 (2):148–152. DOI: 10.1016/j.tvjl.2011.09.013.
  14. Whelehan CJ, Meade KG, Eckersall PD, Young FJ, O’Farrelly C. Experimental Staphylococcus aureus infection of the mammary gland induces region-specific changes in innate immune gene expression. Immunol. Immunopathol. 2011; 140 (3–4): 181–189. DOI: 10.1016/j.vetimm.2010.11.013.
  15. Yang Y, Zhang Y, Zhou L, Cheng G, Tao J, Zhao X. Comparative proteomics study of breast membrane proteins in dairy cow mastitis. National Agricultural Sciences, 2010; 43 (18): 3862–3868.
  16. Yu X, Feng B, He P, Shan L. From chaos to harmony: responses and signaling upon microbial pattern recognition. Annual Rev. Phytopathol. 2017; 55: 109–137. DOI: 10.1146/annurev-phyto-080516-035649.
  17. Zhang W, Li X, Xu T, Ma M, Zhang Y, Gao MQ. Inflammatory responses of stromal fibroblasts to inflammatory epithelial cells are involved in the pathogenesis of bovine mastitis. Cell Res. 2016; 349 (1): 45–52. DOI: 10.1016/j.yexcr.2016.09.016.
  18. Zhang WY, Wang H, Qi S, Wang X, Li X, Zhou K, Zhang Y, Gao MQ. CYP1A1 relieves lipopolysaccharide-induced inflammatory responses in bovine mammary epithelial cells. Mediators Inflamm. 2018; 5: 4093285. DOI: 10.1155/2018/4093285.






WorldCat Logo