Germanium compounds and their role in animal body

R. S. Fedoruk1, I. I. Kovalchuk2, L. M. Mezentseva3, U. I. Tesarivska4, A. Z. Pylypets1, V. H. Kaplunenko5

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1Institute of Animal Biology NAAS,
38 V. Stus str., Lviv, 79034, Ukraine

2Stepan Gzhytsky National University of Veterinary Medicine and Biotechnologies Lviv,
50 Pekarska str., Lviv, 79010, Ukraine

3The National Academy of agrarian sciences of Ukraine,
9 Mykhailo Omelyanovych-Pavlenko str., Kyiv, 01010, Ukraine

4Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives,
11 Donetska str., Lviv, 79019, Ukraine

5Nanomaterials and Nanotechnologies LLC,
27 Vasylkivska str., Kyiv, 03022, Ukraine

Last years literature data and separate research results analysis was carried out concerning biological influence of Germanium compounds at laboratory and productive animals. The article states a comparative effect of mineral and organic Germanium compounds in chemical and biotechnological synthesis, as well as nanotechnological germanium citrate influence on the functioning of the immune, hematological, antioxidant, detoxification, reproductive and nervous systems of animals. The article displays a difference in influence of Germanium compounds on animal body depending on its form, dose and exposure. Benefits of using organic Germanium compounds in chemical, biotechnological and nanotechnological synthesis are highlighted based on a comparative analysis of the own research results, as well as other authors. Functioning analysis of a separate body organs, body systems as well as animal body in total was conducted after animals been exposed to short-term and long-lasting action of various Germanium compounds. Studies results for various Germanium compounds toxicity, their impact on animal productivity and product quality are stated based on the available literature. Comparison of influence effect for some drugs, biologically active additives and products containing Germanium compounds on the animal body was documented. Conclusions are made about the advantages of biological action of organic Germanium compounds, made by biotechnological synthesis using yeast Saccharomyces cerevisiae, and Germanium citrate, obtained on the basis of nanotechnology, regarding the prospects of its use in animal husbandry and veterinary medicine.

Key words: organogermanium compounds, animals, biological processes, toxicity, physiological systems, functions, reproduction

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