RESEARCH OF CHANGES IN THE BLOOD COAGULATION SYSTEMEXPOSURING MICRO- AND NANO RANGE OF LEAD PARTICLES
I. V. Gubar
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State Institution «Institute for occupational health of the National academy of medical sciences of Ukraine», 75 Saksagansky str., Kyiv–03055, Ukraine
The article presents the results of experimental studies of the influence of micro- and nanoparticles of lead on blood coagulation system: on blood plasma of experimental rats (of changes of the coagulometric characteristics in the in vivo conditions) and on its components (of the conformational changes of proteins in the blood coagulation system in vitro conditions). The influence of the lead particles of all sizes on coagulometric characteristics of blood plasma of experimental animals can be described as hypocoagulating. It was established that the decrease in size of lead particles increased their toxic effects on the coagulation system proteins.The sensitivity of proteins to the lead particles of all sizes found in the following sequence: thrombin> fibrinogen> thromboplastin. Revealed changes may be due to the influence of lead micro- and nanoparticles on the structure and activity of proteins that take part in blood coagulation process.
Keywords: LEAD, MICROPARTICLES, NANOPARTICLES, COAGULOMETRIC CHARACTERISTICS, PROTEINS OF BLOOD COAGULATION SYSTEM, DENATURATION
