INFLUENCE OF CORVITIN AND HUMILID ON THE OXIDANT-ANTIOXIDANT SYSTEM IN RATS AFTER INJECTOIN OF ADRENALIN
V. Parоnik1, L. Stepchenko2, L. Diachenko2, A. Lievykh1, A. Shevtsova1
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1GU «Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine»
9 Dzerzhinskyi str., Dnipropetrovsk 49600, Ukraine
2Dnipropetrovsk State Agricultural University,
25 Voroshilov str., Dnipropetrovsk 49600, Ukraine
The results of effect of antioxidant drugs corvitin and gumilid on indicators of lipid peroxidation and the activity of antioxidant enzymes in plasma, erythrocytes and fraction of soluble proteins of cardiac muscle in rats with adrenaline myocardial ischemia are presented.
It was shown that the injection of adrenaline (dose of 0.2 mg/100 g weight in 10 days) results in the increase of intensity of lipid peroxidation and antioxidant enzymes activity in blood and heart. The determination of TBA-active products and antioxidant enzymes in the plasma does not display the state of prooxidant-antioxidant system of the heart muscle. It is proved that the use of corvitin and humilid leads to a decrease of TBA-active products in the cardiac muscle, although in plasma this indicator is almost the same. The activity of glutathione peroxidase and glutathione reductase is reduced by the influence of corvitin and humilid compared to the animals with adrenaline myocardial ischemia, but still elevated relative to control rats. Activity of superoxide dismutase is decreased 5-fold under corvitin and was 1,68±0,21 ng/ml/Hb (norm is 3,12±0,38 ng/ml/Hb).
These results suggest that corvitin and humilid are able to reduce the cardiotoxic effects of adrenaline due to their ability to bind free radicals in heart muscle.
Keywords: ADRENALIN-INDUCED MYOCARDIAL ISHEMIA, CORVITIN, HUMILID, ANTIOXIDANT SYSTEM, TBA-ACTIVE PRODUCTS
