BIOLOGICAL EFFECTS OF DIFFERENT LEVELS OF SOYBEANS CONVENTIONAL AND TRANSGENIC VARIETIES IN THE SECOND-GENERATION FEMALE RATS RATION
O. P. Dolaychuk, R. S. Fedoruk
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NAAS Institute of Animal Biology, Laboratory of ecological physiology and quality of productions,Ukraine, Lviv, 79034, str. Vasyl Stus, 38
Despite many years of experience in the use of feed from GM plants, including soybean, are not fully elucidated the mechanisms of their physiological effects on the organism, particularly on the immunobiological status, reproductive function, detoxification processes, growth and development of an organism in the dynamics of generations, and that led to choice of direction of our research. Soybean both native and transgenic varieties contains many biologically active compounds whose effects are dose-dependent, so our task was to research and study the effect of different amounts of soy in the rats ration. The results of studies of the physiological state of the second-generation female rats under conditions of feeding them and their mothers natural and genetically modified soybeans in an amount of 30 and 50% of the nutritional value of the ration.Effect of soy manifested an increase in blood levels of the investigated glycoprotein and immunological parameters, indicating the activation of immune system and may be caused by nutritional composition of soybean and the presence in it of biologically active compounds with the immunostimulatory effects. The results of determination of phenols fractions indicate tension of detoxification processes in the organism animals of research groups. Feeding conventional or genetically modified soybean female rats (F2) adversely affect their fertility, which may be due to the residual activity of isoflavones in soybean having estrogenic activity. Feeding soybeans females research groups inhibits the viability of offspring in the first 2 months of life, which is more expressed for the group of animals fed GM soy and may be caused by the accumulation in beans and negative influence of the herbicide glyphosate in their body.
Keywords: GLYCOPROTEINS; CIRCULATING IMMUNE COMPLEXES; MOLECULES OF AVERAGE WEIGHT; AMINOTRANSFERASE ACTIVITY; SOYBEANS; GMO
