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Omelyanchik LO, Tavrog ML, Hromokovska TS, Pototska OI. Morphofunctional basis of the cutaneous immune system. Bìol Tvarin. 2025; 27 (3): 20–26. DOI: 10.15407/animbiol27.03.020.
https://doi.org/10.15407/animbiol27.03.020
Received 15.08.2025 ▪ Revision 06.10.2025 ▪ Accepted 14.10.2025 ▪ Published online 22.10.2025

Морфофункціональні основи імунної системи шкіри

Л. О. Омелянчик¹, М. Л. Таврог², Т. С. Громоковська², О. І. Потоцька²
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¹Запорізький національний університет, вул. Університетська, 66, м. Запоріжжя, 69011, Україна
²Запорізький державний медико-фармацевтичний університет, бульв. Марії Приймаченко, 26, м. Запоріжжя, 69035, Україна

Стаття надає систематичний огляд сучасних уявлень про морфофункціональні основи імунної системи шкіри, її клітинний склад та інтеграцію в складний мережевий нейро-імунно-ендокринний механізм. Наведено характеристику основних типів імунокомпетентних клітин: кератиноцитів, дендритних клітин (Лангерганса, мієлоїдних, плазматичних), макрофагів, мастоцитів, лімфоцитів та їх ролі у підтримці гомеостазу та захисті шкіри від зовнішніх і внутрішніх чинників. наукові бази. Для пошуку літератури використані сучасні бази (Scopus, PubMed, Web of Science). Окремо висвітлено концепцію периферійної лімфоїдної тканини шкіри (iSALT) та її значення в регуляції місцевого імунітету. Висновки підкреслюють складність взаємодій між клітинними компонентами шкіри і системними імунними реакціями.

Ключові слова: імунна система шкіри, кератиноцити, лімфоцити, дендритні клітини, макрофаги, мастоцити, імунокомпетентні клітини

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